I use Reason for live stuff if I am in the lead. If backup, I still use Reason and the B4 organ program. I use a 1/8" male to 1/4" female so I can plug a instrument cable from the adapter to the amp. You can also use a 1/8" male to male cable to the laptop to the amp. Then just get a 1/8" female to 1/4" male to plug to amp. either way will work. For midi controllers, anything will work as long the computer and the programs can recognize it.